Purified CD antibodies and fluorescent labeled conjugates

AAT Bioquest has expanded their catalog of Cluster of Differentiation (CD) cell surface molecules, a constantly-growing focus in the continued advancement of immune research. Because these molecules are expressed at varying degrees and cell types, multiparameter flow cytometric analysis utilizing two or more combinations of fluorescently labeled CD antibodies enables clear resolution of particular cell type or subtype.

They have a extensive catalog of CD antibodies including CD3, CD8, CD19 and CD40 antibodies. These CD antibodies are purified by affinity chromatography and conjugated to a variety of fluorophores under optimal conditions that minimize unconjugated fluorophore and antibody. Available fluorophores include:
  • iFluor™ dyes - bright, photostable dyes with optimized flow cytometry (FACS), fluorescence imaging and in vivo imaging applications.
  • mFluor™ dyes - bright, photostable dyes with optimized for flow cytometry (FACS) applications.
  • Alexa Fluor® dyes - suitable for flow cytometry (FACS) and fluorescence imaging applications.
  • Classic dyes - suitable for flow cytometry (FACS) and fluorescence imaging applications.
  • Phycobiliproteins and Tandem dyes - intensely bright dyes for flow cytometry (FACS) and multiparametric analysis.

Popular CD antibodies

Overview of monoclonal anti-human CD antibodies.

CD3

Functions primarily as a T cell co-receptor promoting the activation of cytotoxic T cells (CD8+ T cells) and T helper cells (CD4+ T cells), and ultimately helping to shape the adaptive immune response.

ImmunogenClassSpecies ReactivityHost, IsotypeCloneApplications
Recognizes CD3ε-chainMonoclonalHumanMouse, IgG1HIT3bFC, IHC-F, IF
Recognizes CD3ε-chainMonoclonalHumanMouse, IgG1, kappaSK7FC, IHC
Recognizes CD3ε-chainMonoclonalHumanMouse, IgG2a, kappaHIT3aFC, FN, IHC-F, IP
Recognizes CD3ε-chainMonoclonalHumanMouse, IgG1, kappaUCHT1FC, FN, IHC-F, ICC, IP, WB
Recognizes CD3ε-chainMonoclonalHumanMouse, IgG2a, kappaOKT-3FC

CD4 (Leu3, T4)

Unfortunately serves as a high affinity receptor for HIV, which the virus utilizes for entry into host T cells. CD4 counts are frequently used to assess the health of a patient's immune system infected with HIV.

ImmunogenClassSpecies ReactivityHost, IsotypeCloneApplications
Recognizes CD4MonoclonalHumanMouse, IgG1, kappaRPA-T4FC, IHC-F, IF, ELISA, WB
Recognizes CD4MonoclonalHumanMouse, IgG1, kappaSK3FC, IHC-F, IF, ELISA, WB
Recognizes CD4MonoclonalHumanMouse, IgG2b, kappaOKT-4FC, IHC-F, IF, ELISA, WB
Recognizes CD4MonoclonalHumanMouse, IgG2b, kappaHIT4aFC, IHC-F, IF, ELISA, WB

CD8 (TCR, Leu2, T8)

Plays a pivotal role in T cell signaling, assists CD8+ T cells in the recognition of antigen presenting MHC class I molecules, and can serve as a cell adhesion molecule.

ImmunogenClassSpecies ReactivityHost, IsotypeCloneApplications
Recognizes human CD8αMonoclonalHumanMouse, IgG1, kappaHIT8aFC, ELISA, IHC, IF, WB
Recognizes human CD8αMonoclonalHumanMouse, IgG1, kappaSK1FC, ELISA, IHC, IF, WB
Recognizes human CD8αMonoclonalHumanMouse, IgG2aOKT-8FC, ELISA, IHC, IF, WB

CD14

Plays a key role as a co-receptor for several Toll-like receptors (TLRs) facilitating in the detection of bacterial lipopolysaccharides (LPS).

ImmunogenClassSpecies ReactivityHost, IsotypeCloneApplications
Recognizes human CD14MonoclonalHumanMouse, IgG1, kappa61D3FC, ELISA, IHC, IF, WB
Recognizes human CD14MonoclonalHumanMouse, IgMHI221FC, ELISA, IHC, IF, WB

CD19 (Leu12)

Serves as a reliable biomarker for B lymphocytes and can potentially be used as a diagnostic tool for identifying lymphoma subtypes.

ImmunogenClassSpecies ReactivityHost, IsotypeCloneApplications
Recognizes CD19MonoclonalHumanMouse, IgG1, kappaHI19aFC, IHC-F, IF, ELISA, WB
Recognizes CD19MonoclonalHumanMouse, IgG1, kappaHIB19FC, IHC-F, IF, ELISA, WB
Recognizes CD19MonoclonalHumanMouseSJ25C1FC, IHC-F, IF, ELISA, WB

CD34 (Mucosialin)

Known to facilitate cell-cell adhesion, and is necessary for the entry of T cells into lymph nodes a critical event that is essential for adaptive immunity to function properly.

ImmunogenClassSpecies ReactivityHost, IsotypeCloneApplications
Recognizes CD34MonoclonalHumanMouse, IgG1, kappa4H11FC, IHC-F, IF, ELISA, WB

CD40 (TNFRSF5)

Functions mainly as a co-stimulatory protein that binds to CD154, also known as CD40 ligand or CD40L, which is present on activated T helper cells.

ImmunogenClassSpecies ReactivityHost, IsotypeCloneApplications
Recognizes CD40MonoclonalHumanMouse, IgG2HI40aFC, IHC-F, IF, ELISA, WB

CD45 (PTPRC)

Necessary for a variety of cellular processes including efficient T- and B-cell antigen receptor mediated signal transduction, cell growth, differentiation and oncogenic transformation.

ImmunogenClassSpecies ReactivityHost, IsotypeCloneApplications
Recognizes all isoforms of human CD45MonoclonalHumanMouse, IgG1HI30FC, IHC, IHC-F, IF
Recognizes all isoforms of human CD45MonoclonalHumanMouse, IgG1HI151FC, IF
Recognizes all isoforms of human CD45MonoclonalHumanMouse, IgG1HI185FC, IF
Recognizes all isoforms of human CD45MonoclonalHumanMouse, IgG1, kappa2D1FC, IHC, IHC-F, IF
Recognizes all isoforms of human CD45MonoclonalHumanMouse, IgG2aHI73FC, IHC, IHC-F, IF
Recognizes human CD45ROMonoclonalHumanMouse, IgG2a, kappaUCHL1FC, IHC-F, IF
Recognizes human CD45RAMonoclonalHumanMouse, IgG2b, kappaHI100FC, IF

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