SARS-CoV-2 (COVID-19) by GeneTex



With SARS-CoV-2 now reaching pandemic status, researchers and clinicians have been working furiously to learn more about the virus’s biology and pathogenesis as well as how to treat the more clinically aggressive COVID-19 cases. As with any viral pathogen, understanding how SARS-CoV-2 enters host cells is of great significance.

In their study published very recently in Cell, Hoffmann et al. confirm findings reported by Zhou et al. that angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for SARS-CoV-2, as it is for SARS-CoV (2, 3). In addition, they identify the serine protease TMPRSS2 as a critical factor in the priming of the SARS-CoV-2 spike (S) protein, an essential step for viral entry into host cells through fusion of the viral and cellular membranes. The authors also demonstrate that the serine protease inhibitor camostat mesylate, an agent that has already seen clinical application as a treatment for chronic pancreatitis in Japan, is able to interfere with SARS-CoV-2 infection of lung cells. Finally, the study presents data that antibodies generated to SARS-CoV S protein may have some protective activity against SARS-CoV-2. Together, this work expands our knowledge of key factors involved in SARS-CoV-2’s entry into cells and reveals some promising avenues for SARS-CoV-2-directed therapies.

GeneTex offers an extensive line of research antibodies and proteins to support the study of SARS-CoV-2, several of which were validated using virus-infected cell lysates.

 
 
 
SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604)
 SARS-CoV / SARS-CoV-2 (COVID-19) nucleocapsid antibody [6H3] (GTX632269)
 SARS-CoV-2 (COVID-19) nucleocapsid protein (GTX135357-pro)
 Human ACE2 protein (active) (GTX01179-pro)

A world problem needing a world response



Products to support the study of SARS-CoV-2

Cat. No.DescriptionHostClonalityApplication

Antibodies

GTX15349ACE2 antibodyRabbitPolyclonalWB, ICC/IF, IHC-P, ELISA
GTX31680ACE2 antibodyRabbitPolyclonalWB, IHC-P, ELISA
GTX52524ACE2 antibody [11A31]MouseMonoclonalWB, IHC-P
GTX101395ACE2 antibody [N1N2], N-termMouseMonoclonalIHC-P, WB
GTX01160ACE2 antibody [SN0754]RabbitMonoclonalWB, ICC/IF, IHC-P
GTX134866MERS-CoV M protein antibodyRabbitPolyclonalWB
GTX134868MERS-CoV Nucleoprotein antibodyRabbitPolyclonalWB
GTX134869MERS-CoV ORF4a antibodyRabbitPolyclonalWB
GTX134880MERS-CoV ORF4a antibodyRabbitPolyclonalWB
GTX134870MERS-CoV ORF4b antibodyRabbitPolyclonalWB
GTX134864MERS-CoV S1 protein antibodyRabbitPolyclonalWB
GTX134875MERS-CoV S1 protein antibodyRabbitPolyclonalWB
GTX632604SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9]MouseMonoclonalWB, FACS
GTX01555SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022]HumanMonoclonalELISA, Neutralizing/Blocking
GTX01556SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022]RabbitMonoclonalELISA, Neutralizing/Blocking
GTX632602SARS-CoV 7a protein antibody [3C9]MouseMonoclonalWB, ICC/IF
GTX83200SARS-CoV E2 antibody [4A6C9]MouseMonoclonalWB, ELISA
GTX83199SARS-CoV M antibody [2H2C4]MouseMonoclonalWB, ELISA
GTX632696SARS-CoV NS8 antibody [5A10]MouseMonoclonalWB
GTX30793SARS-CoV Nucleocapsid antibody [18F629.1]MouseMonoclonalWB
GTX632269SARS-CoV Nucleocapsid antibody [6H3]MouseMonoclonalWB, ICC/IF
GTX36802SARS-CoV Nucleoprotein antibody [3851]MouseMonoclonalWB, ICC/IF, ELISA
GTX36801SARS-CoV Nucleoprotein antibody [3861]MouseMonoclonalWB, ICC/IF, ELISA
GTX632603SARS-CoV SDelta3 antibody [7G12]MouseMonoclonalWB, IP
GTX135612SARS-CoV-2 (COVID-19) nsp1 antibodyRabbitPolyclonalWB
GTX135357SARS-CoV-2 (COVID-19) nucleocapsid antibodyRabbitPolyclonalWB, ICC/IF
GTX135361SARS-CoV-2 (COVID-19) nucleocapsid antibody (unique SARS-CoV-2 target antigen)RabbitPolyclonalWB
GTX635680SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL146]RabbitMonoclonalWB
GTX635678SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL249]RabbitMonoclonalWB, ELISA
GTX635679SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]RabbitMonoclonalWB, ELISA
GTX635686SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL448]RabbitMonoclonalWB, ICC/IF, ELISA
GTX635687SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL453]RabbitMonoclonalWB, ICC/IF, ELISA
GTX635688SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL455]RabbitMonoclonalWB, ICC/IF, ELISA
GTX635712SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL455-MS]MouseMonoclonalWB, ICC/IF, ELISA, sELISA
GTX635685SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL5410]RabbitMonoclonalWB, ELISA, sELISA
GTX635689SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL5511]RabbitMonoclonalWB, ICC/IF, ELISA
GTX135591SARS-CoV-2 (COVID-19) ORF8 antibodyRabbitPolyclonalWB
GTX135614SARS-CoV-2 (COVID-19) PLpro (nsp3) antibodyRabbitPolyclonalWB
GTX135467SARS-CoV-2 (COVID-19) RdRp (nsp12) antibodyRabbitPolyclonalWB
GTX135356SARS-CoV-2 (COVID-19) spike antibodyRabbitPolyclonalWB, ICC/IF
GTX135360SARS-CoV-2 (COVID-19) spike antibody (unique SARS-CoV-2 target antigen)RabbitPolyclonalWB
GTX135385SARS-CoV-2 (COVID-19) Spike RBD antibodyRabbitPolyclonalWB, ICC/IF
GTX635692SARS-CoV-2 (COVID-19) Spike RBD antibody [HL257]RabbitMonoclonalWB, ICC/IF, ELISA
GTX135384SARS-CoV-2 (COVID-19) Spike S1 antibodyRabbitPolyclonalWB, ICC/IF
GTX635708SARS-CoV-2 (COVID-19) Spike S1 antibody [GT263]MouseMonoclonalWB
GTX635656SARS-CoV-2 (COVID-19) Spike S1 antibody [HL1]RabbitMonoclonalWB, ICC/IF, ELISA, sELISA
GTX635671SARS-CoV-2 (COVID-19) Spike S1 antibody [HL134]RabbitMonoclonalWB, ICC/IF, ELISA
GTX635713SARS-CoV-2 (COVID-19) Spike S1 antibody [HL13402]RabbitMonoclonalWB, ELISA
GTX635672SARS-CoV-2 (COVID-19) Spike S1 antibody [HL263]RabbitMonoclonalWB, ICC/IF, ELISA
GTX635654SARS-CoV-2 (COVID-19) Spike S1 antibody [HL6]RabbitMonoclonalWB, ICC/IF, ELISA, sELISA
GTX135386SARS-CoV-2 (COVID-19) Spike S2 / S2' antibodyRabbitPolyclonalICC/IF, ELISA, sELISA
GTX635693SARS-CoV-2 (COVID-19) Spike S2 antibody [HL237]RabbitMonoclonalWB, ICC/IF
GTX64544TMPRSS2 antibodyRabbitPolyclonalWB, IHC-P
GTX100743TMPRSS2 antibody [N2C3]RabbitPolyclonalWB
GTX81494TMPRSS2 antibody, InternalRabbitPolyclonalWB, FACS

ELISA pairs

GTX500042SARS-CoV-2 (COVID-19) Nucleocapsid ELISA Pair [HL5410 / HL455-MS]ELISA
GTX500041SARS-CoV-2 (COVID-19) Spike ELISA Pair - [1A9 / HL263]
GTX500040SARS-CoV-2 (COVID-19) Spike ELISA Pair - [1A9 / HL6]
GTX500043SARS-CoV-2 (COVID-19) Spike ELISA Pair [1A9 / HL13402]ELISA

Proteins

GTX15354ACE2 peptide (169-183)Neutralizing/Blocking
GTX15351ACE2 peptide (192-208)Neutralizing/Blocking
GTX15353ACE2 peptide (2-18)Neutralizing/Blocking
GTX15352ACE2 peptide (788-805)Control, Neutralizing/Blocking
GTX135683-proHuman ACE2 (ECD) protein, mouse IgG Fc tagWB
GTX01550-proHuman ACE2 protein, His and Avi tag
GTX135653-proMERS-CoV nucleocapsid protein
GTX01557-proSARS-CoV-2 (COVID-19) 3C-like Proteinase protein, His and Avi tag
GTX135648-proSARS-CoV-2 (COVID-19) 3C-like Proteinase protein, His tag
GTX01565-proSARS-CoV-2 (COVID-19) Envelope Protein, GST and His Tag
GTX01547-proSARS-CoV-2 (COVID-19) Envelope protein, His and Avi tag
GTX135357-proSARS-CoV-2 (COVID-19) nucleocapsid protein
GTX135592-proSARS-CoV-2 (COVID-19) nucleocapsid proteinWB, ELISA
GTX01546-proSARS-CoV-2 (COVID-19) Spike RBD protein, His tag (active)Functional Assay
GTX01548-proSARS-CoV-2 (COVID-19) Spike S1 protein, His and Avi tag (active)Functional Assay
GTX01554-proSARS-CoV-2 (COVID-19) Spike S1 protein, His tag (active)Functional Assay
GTX01559-proSARS-CoV-2 (COVID-19) Spike S2 (ECD) protein, human IgG Fc tag
GTX135684-proSARS-CoV-2 (COVID-19) Spike S2 (ECD) protein, mouse IgG Fc tag

Inhibitors

GTX01523Camostat mesylate

Cell pellet blocks

GTX435642SARS-CoV-2 (COVID-19) Envelope FFPE Cell Pellet BlockIHC-P
GTX435645SARS-CoV-2 (COVID-19) Membrane FFPE Cell Pellet BlockIHC-P
GTX435641SARS-CoV-2 (COVID-19) Nucleocapsid FFPE Cell Pellet BlockIHC-P
GTX435640SARS-CoV-2 (COVID-19) Spike FFPE Cell Pellet BlockIHC-P
GTX435643SARS-CoV-2 (COVID-19) Spike S1 FFPE Cell Pellet BlockIHC-P
GTX435644SARS-CoV-2 (COVID-19) Spike S2 FFPE Cell Pellet BlockIHC-P

Overexpression lysates

GTX535667MERS-CoV Spike overexpression 293T whole cell lysateWB
GTX535668SARS-CoV Spike overexpression 293T whole cell lysateWB
GTX535665SARS-CoV-2 (COVID-19) Nucleocapsid overexpression 293T whole cell lysate
GTX535664SARS-CoV-2 (COVID-19) Spike overexpression 293T whole cell lysate
GTX535663SARS-CoV-2 (COVID-19) Spike S1 overexpression 293T whole cell lysate

References:

  1. Nature News. 11 March 2020.
  2. Zhou et al. Nature 579, 270-273 (2020).
  3. Hoffmann et al. Cell 181, 1-10 (2020).

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