SARS-CoV-2 (COVID-19) by GeneTex



With SARS-CoV-2 now reaching pandemic status, researchers and clinicians have been working furiously to learn more about the virus’s biology and pathogenesis as well as how to treat the more clinically aggressive COVID-19 cases. As with any viral pathogen, understanding how SARS-CoV-2 enters host cells is of great significance.

In their study published very recently in Cell, Hoffmann et al. confirm findings reported by Zhou et al. that angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for SARS-CoV-2, as it is for SARS-CoV (2, 3). In addition, they identify the serine protease TMPRSS2 as a critical factor in the priming of the SARS-CoV-2 spike (S) protein, an essential step for viral entry into host cells through fusion of the viral and cellular membranes. The authors also demonstrate that the serine protease inhibitor camostat mesylate, an agent that has already seen clinical application as a treatment for chronic pancreatitis in Japan, is able to interfere with SARS-CoV-2 infection of lung cells. Finally, the study presents data that antibodies generated to SARS-CoV S protein may have some protective activity against SARS-CoV-2. Together, this work expands our knowledge of key factors involved in SARS-CoV-2’s entry into cells and reveals some promising avenues for SARS-CoV-2-directed therapies.

GeneTex offers an extensive line of research antibodies and proteins to support the study of SARS-CoV-2, several of which were validated using virus-infected cell lysates.

 
 
 
SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604)
 SARS-CoV / SARS-CoV-2 (COVID-19) nucleocapsid antibody [6H3] (GTX632269)
 SARS-CoV-2 (COVID-19) nucleocapsid protein (GTX135357-pro)
 Human ACE2 protein (active) (GTX01179-pro)

A world problem needing a world response



Products to support the study of SARS-CoV-2

Cat. No.DescriptionHostClonalityApplication
Antibodies
GTX15349ACE2 antibodyRabbitPolyclonalWB, ICC/IF, IHC-P, ELISA
GTX31680ACE2 antibodyRabbitPolyclonalWB, IHC-P, ELISA
GTX52524ACE2 antibody [11A31]MouseMonoclonalWB, IHC-P
GTX101395ACE2 antibody [N1N2], N-termMouseMonoclonalIHC-P, WB
GTX01160ACE2 antibody [SN0754]RabbitMonoclonalWB, ICC/IF, IHC-P
GTX134866MERS-CoV M protein antibodyRabbitPolyclonalWB
GTX134868MERS-CoV Nucleoprotein antibodyRabbitPolyclonalWB
GTX134869MERS-CoV ORF4a antibodyRabbitPolyclonalWB
GTX134880MERS-CoV ORF4a antibodyRabbitPolyclonalWB
GTX134870MERS-CoV ORF4b antibodyRabbitPolyclonalWB
GTX134864MERS-CoV S1 protein antibodyRabbitPolyclonalWB
GTX134875MERS-CoV S1 protein antibodyRabbitPolyclonalWB
GTX632604SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9]MouseMonoclonalWB, FACS
GTX01555SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022]HumanMonoclonalELISA, Neutralizing/Blocking
GTX01556SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022]RabbitMonoclonalELISA, Neutralizing/Blocking
GTX632602SARS-CoV 7a protein antibody [3C9]MouseMonoclonalWB, ICC/IF
GTX83200SARS-CoV E2 antibody [4A6C9]MouseMonoclonalWB, ELISA
GTX83199SARS-CoV M antibody [2H2C4]MouseMonoclonalWB, ELISA
GTX632696SARS-CoV NS8 antibody [5A10]MouseMonoclonalWB
GTX30793SARS-CoV Nucleocapsid antibody [18F629.1]MouseMonoclonalWB
GTX632269SARS-CoV Nucleocapsid antibody [6H3]MouseMonoclonalWB, ICC/IF
GTX36802SARS-CoV Nucleoprotein antibody [3851]MouseMonoclonalWB, ICC/IF, ELISA
GTX36801SARS-CoV Nucleoprotein antibody [3861]MouseMonoclonalWB, ICC/IF, ELISA
GTX632603SARS-CoV SDelta3 antibody [7G12]MouseMonoclonalWB, IP
GTX135357SARS-CoV-2 (COVID-19) nucleocapsid antibodyRabbitPolyclonalWB, ICC/IF
GTX135361SARS-CoV-2 (COVID-19) nucleocapsid antibody (unique SARS-CoV-2 target antigen)RabbitPolyclonalWB
GTX635680
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL146]
RabbitMonoclonalWB
GTX635678
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL249]
RabbitMonoclonalWB, ELISA
GTX635679
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]
RabbitMonoclonalWB, ELISA
GTX635686
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL448]
RabbitMonoclonalWB, ICC/IF, ELISA
GTX635687
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL453]
RabbitMonoclonalWB, ICC/IF, ELISA
GTX635688
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL455]
RabbitMonoclonalWB, ICC/IF, ELISA
GTX635689
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL5511]
RabbitMonoclonalWB, ICC/IF, ELISA
GTX135356SARS-CoV-2 (COVID-19) spike antibodyRabbitPolyclonalWB, ICC/IF
GTX135360SARS-CoV-2 (COVID-19) spike antibody (unique SARS-CoV-2 target antigen)RabbitPolyclonalWB
GTX135385
SARS-CoV-2 (COVID-19) Spike RBD antibody
RabbitPolyclonalWB, ICC/IF
GTX135384
SARS-CoV-2 (COVID-19) Spike S1 antibody
RabbitPolyclonalWB, ICC/IF
GTX635656
SARS-CoV-2 (COVID-19) Spike S1 antibody [HL1]
RabbitMonoclonal WB, ICC/IF, ELISA, sELISA
GTX635671
SARS-CoV-2 (COVID-19) Spike S1 antibody [HL134]
RabbitMonoclonalWB, ICC/IF, ELISA
GTX635672
SARS-CoV-2 (COVID-19) Spike S1 antibody [HL263]
RabbitMonoclonalWB, ICC/IF, ELISA
GTX635654
SARS-CoV-2 (COVID-19) Spike S1 antibody [HL6]
RabbitMonoclonalWB, ICC/IF, ELISA, sELISA
GTX135386
SARS-CoV-2 (COVID-19) Spike S2 / S2' antibody
RabbitPolyclonalICC/IF, ELISA, sELISA
GTX100743TMPRSS2 antibody [N2C3]RabbitPolyclonalWB
ELISA pairs
GTX500041
SARS-CoV-2 (COVID-19) Spike ELISA Pair - [1A9 / HL263]
   
GTX500040
SARS-CoV-2 (COVID-19) Spike ELISA Pair - [1A9 / HL6]
   
Proteins
GTX01550-proHuman ACE2 protein, His and Avi tag
GTX01557-proSARS-CoV-2 (COVID-19) 3C-like Proteinase protein, His and Avi tag
GTX135648-pro
SARS-CoV-2 (COVID-19) 3C-like Proteinase protein, His tag
   
GTX01547-proSARS-CoV-2 (COVID-19) Envelope protein, His and Avi tag
GTX135357-proSARS-CoV-2 (COVID-19) nucleocapsid protein
GTX135592-proSARS-CoV-2 (COVID-19) nucleocapsid proteinWB, ELISA
GTX01546-proSARS-CoV-2 (COVID-19) Spike RBD protein, His tag (active)Functional Assay
GTX01548-proSARS-CoV-2 (COVID-19) Spike S1 protein, His and Avi tag (active)Functional Assay
GTX01554-proSARS-CoV-2 (COVID-19) Spike S1 protein, His tag (active)Functional Assay
GTX135684-pro
SARS-CoV-2 (COVID-19) Spike S2 (ECD) protein, mouse IgG Fc tag
   
GTX15354ACE2 peptide (169-183)Neutralizing/Blocking
GTX15351ACE2 peptide (192-208)Neutralizing/Blocking
GTX15353ACE2 peptide (2-18)Neutralizing/Blocking
GTX15352ACE2 peptide (788-805)Control, Neutralizing/Blocking
Inhibitors
GTX01523Camostat mesylate
Cell pellet blocks
GTX435642
SARS-CoV-2 (COVID-19) Envelope FFPE Cell Pellet Block
  IHC-P
GTX435645
SARS-CoV-2 (COVID-19) Membrane FFPE Cell Pellet Block
  IHC-P
GTX435641
SARS-CoV-2 (COVID-19) Nucleocapsid FFPE Cell Pellet Block
  IHC-P
GTX435640
SARS-CoV-2 (COVID-19) Spike FFPE Cell Pellet Block
  IHC-P
GTX435643
SARS-CoV-2 (COVID-19) Spike S1 FFPE Cell Pellet Block
  IHC-P
GTX435644
SARS-CoV-2 (COVID-19) Spike S2 FFPE Cell Pellet Block
  IHC-P
Overexpression lysates
GTX535665
SARS-CoV-2 (COVID-19) Nucleocapsid overexpression 293T whole cell lysate
   
GTX535664
SARS-CoV-2 (COVID-19) Spike overexpression 293T whole cell lysate
   
GTX535663
SARS-CoV-2 (COVID-19) Spike S1 overexpression 293T whole cell lysate
   

References:

  1. Nature News. 11 March 2020.
  2. Zhou et al. Nature 579, 270-273 (2020).
  3. Hoffmann et al. Cell 181, 1-10 (2020).

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