Overview
- SupplierGeneTex
- Product NamePTEN antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.68 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Efficient Generation of Somatic Cell Nuclear Transfer-Competent Porcine Cells with Mutated Alleles at Multiple Target Loci by Using CRISPR/Cas9 Combined with Targeted Toxin-Based Selection System. Sato M et al., 2017 Dec 4, Int J Mol SciRead more
- HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines. Kim JW et al., 2014 May, Genes CancerRead more
- MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression. Mei S et al., 2015, PLoS OneRead more
- miR-214 targets the PTEN-mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer. Liu J et al., 2017 Nov, Oncol LettRead more
- Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway. Qian L et al., 2018 Feb, CytotechnologyRead more
- Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells. Chen NC et al., 2016 Feb 3, Sci RepRead more
- Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor beta repression. Mak P et al., 2015 Mar 31, Cell RepRead more
- RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma. Pal SK et al., 2015 Jan, Mol Cancer ResRead more
- The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of miR-486-5p and myostatin. Chang YC et al., 2020 Oct 15, Arch Biochem BiophysRead more
- UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity. Huang AM et al., 2011 Jul 1, Biochem PharmacolRead more