AMACR / p504S Antibody (Prostate Cancer Marker)
ORB534283
Overview
- SupplierBiorbyt
- Product NameAMACR / p504S Antibody (Prostate Cancer Marker)
- Delivery Days Customer16
- ApplicationsWestern Blot
- Applications SupplierWestern blot: 0.5-1ug/ml,IHC (FFPE): 1-2ug/ml for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1) IHC-P, WB
- CertificationResearch Use Only
- Clone ID2MACR-1
- IsotypeIgG
- Scientific DescriptionThe AMACR gene encodes the racemase Alpha-methylacyl-CoA. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [RefSeq]
- UNSPSC12352203