anti-AIM2 (human), mAb (3B10)

Catalog number: AG-20B-0040-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 310.00
Expected delivery time: 7 days

Product specifications for - anti-AIM2 (human), mAb (3B10)

Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoCytoChemistry, Western Blot
Clonality: Monoclonal
Isotype: IgG1
Source: Purified from concentrated hybridoma tissue culture supernatant.
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.
Clone ID: 3B10
Swiss prot ID: O14862
Safety information: 
Additional information: 
Synonyms: AG-20B-0040-C100; AdipoGen Life Sciences; Interferon-inducible Protein AIM2; Absent in Melanoma 2
Expression of IFI 16 in epithelial cells and lymphoid tissues: W. Wei, et al.; Histochem. Cell Biol. 119, 45 (2003) Read more
Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2: K.S. Cresswell, et al.; BBRC 326, 417 (2005) Read more
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA: T. Fernandes-Alnemri, et al.; Nature 458, 509 (2009) Read more
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC: V. Hornung, et al.; Nature 458, 514 (2009) Read more
A novel flow cytometric method to assess inflammasome formation: D.P. Sester, et al.; J. Immunol. 194, 455 (2015) Read more
Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection: C. Sun, et al.; J. Immunol. 194, 1819 (2015) Read more