anti-ARAP1 antibody [ARAP1-2]

Arigo Biolaboratories

anti-ARAP1 antibody [ARAP1-2]

23

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

ARAP1-2

1 mg/ml

Unconjugated

>95%

ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; centaurin-delta-2; CENTD2; cnt-d2

Mouse

IgG1

ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.

Human

-20°C

12352203