anti-beta III Tubulin antibody [AA10]

Arigo Biolaboratories

anti-beta III Tubulin antibody [AA10]

23

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

AA10

Unconjugated

Tubb3

tubulin, beta 3 class III

neuron-specific class III beta-tubulin; tubulin beta-3 chain

Mouse

IgG

Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of Tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III Tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of Tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III Tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)

Rat

-20°C

12352203