anti-BIN1 antibody
ARG64648
ApplicationsWestern Blot
Product group Antibodies
ReactivityBovine, Canine, Human, Mouse, Porcine, Rat
TargetBIN1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-BIN1 antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.5 mg/ml
- ConjugateUnconjugated
- Gene ID274
- Target nameBIN1
- Target descriptionbridging integrator 1
- Target synonymsAMPH2; amphiphysin II; amphiphysin-like protein; AMPHL; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; CNM2; myc box-dependent-interacting protein 1; SH3P9
- HostGoat
- IsotypeIgG
- Scientific DescriptionThis gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]
- ReactivityBovine, Canine, Human, Mouse, Porcine, Rat
- Storage Instruction-20°C
- UNSPSC12352203