anti-BRAP antibody

Arigo Biolaboratories

anti-BRAP antibody

23

Western Blot

Research Use Only

Monoclonal

1.8 mg/ml

Unconjugated

BRAP

BRCA1 associated protein

BRAP2; BRCA1-associated protein; galectin-2-binding protein; IMP; impedes mitogenic signal propagation; renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; RNF52

Mouse

IgG1

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Human

-20°C

12352203