anti-Caspase-1 (p10) (mouse), mAb (Casper-2)

Catalog number: AG-20B-0044-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 370.00
Expected delivery time: 7 days

Product specifications for - anti-Caspase-1 (p10) (mouse), mAb (Casper-2)

Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot
Clonality: Monoclonal
Isotype: IgG2a
Source: Purified from concentrated hybridoma tissue culture supernatant.
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Clone ID: Casper-2
Swiss prot ID: P29452
Safety information: 
Additional information: 
Synonyms: AG-20B-0044-C100; AdipoGen Life Sciences; Interleukin-1beta Convertase; IL-1BC; Interleukin-1beta-converting Enzyme; ICE
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation: M. Yabal, et al.; Cell Rep. 7, 1796 (2014) Read more
AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages: Y. Wang, et al.; Ann. Rheum. Dis. 75, 286 (2016) Read more
Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome: C. Guo, et al.; Immunity (epub ahead of print) (2016) Read more