anti-Caspase-1 (p20) (mouse), mAb (Casper-1) (Biotin)

Catalog number: AG-20B-0042B-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 400.00
Expected delivery time: 7 days

Product specifications for - anti-Caspase-1 (p20) (mouse), mAb (Casper-1) (Biotin)

Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoHistoChemistry, ImmunoPrecipitation, Western Blot
Clonality: Monoclonal
Isotype: IgG1
Source: Purified from concentrated hybridoma tissue culture supernatant.
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 0.5mg/ml
Form supplied: Liquid. In PBS containing 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Clone ID: Casper-1
Swiss prot ID: P29452
Safety information: 
Additional information: 
Synonyms: AG-20B-0042B-C100; AdipoGen Life Sciences; Interleukin-1beta Convertase; IL-1BC; Interleukin-1beta-converting Enzyme; ICE
Measuring the inflammasome: O. Gross; Methods Mol. Biol. 844, 199 (2012) Read more
Inflammasome Activators Induce Interleukin-1alpha Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1: O. Gross, et al.; Immunity 36, 388 (2012) Read more
Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation: Y. Yan, et al.; Immunity 38, 1154 (2013) Read more
LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition: J. Jin, et al.; Nat. Commun. 4, 2075 (2013) Read more
iGLuc: a luciferase-based inflammasome and protease activity reporter: E. Bartok, et al.; Nat. Methods 10, 147 (2013) Read more
Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection: C. Lupfer, et al.; Nat. Immunol. 14, 480 (2013) Read more
Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease: J.L. McAuley, et al.; PLoS Pathog. 9, e1003392 (2013) Read more
Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop: C. Juruj, et al.; Front. Cell. Infect. Microbiol. 3, 14 (2013) Read more
Inflammasome Activation by Altered Proteostasis: J.N. Shin, et al.; J. Biol. Chem. 288, 35886 (2013) Read more
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes: P. Gurung, et al.; J. Immunol. 192, 1835 (2014) Read more