anti-Caspase-12 (mouse), mAb (12G6)

Catalog number: AG-20T-0141-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 280.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-Caspase-12 (mouse), mAb (12G6)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ELISA; Flow Cytometry; Western Blot
Species: Mouse
Target: Casp12
Target description: caspase 12
Isotype: IgG1 Kappa
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 0.02% sodium azide.
Storage instructions: -20-¦C
Scientific information: 
Scientific info: Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localized to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues and is expressed at high levels in skeletal muscle, heart, lung and kidney and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed. - Monoclonal Antibody. Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11. Isotype: Rat IgG1kappa. Clone: 12G6. Applications: ELISA, FACS, WB. Liquid. In PBS containing 0.02% sodium azide. Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localized to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues and is expressed at high levels in skeletal muscle, heart, lung and kidney and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Clone ID: 12G6
Gene ID: 12364
Swiss prot ID: O08736
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: CASP-12; caspase-12