anti-Caspase-4 /11 (p20), mAb (Flamy-1) (Biotin)

Catalog number: AG-20B-0060B-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 350.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-Caspase-4 /11 (p20), mAb (Flamy-1) (Biotin)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoPrecipitation, Western Blot
Species: Human, Mouse
Clonality: Monoclonal
Conjugation: Biotin
Isotype: IgG2b Kappa
Source: Purified from concentrated hybridoma tissue culture supernatant.
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1mg/ml
Form supplied: Liquid. In PBS containing 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Inflammatory caspases (also known as group I caspases) are encoded by three main genes in humans, caspase-1, caspase-4 and caspase-5 and three main genes in mouse, caspase-1, caspase-11 and caspase-12. Caspase-11 is the murine orthologue of human caspase-4 and -5. Murine caspase-11 is a poorly characterized member of the caspase-1 subfamily. Caspase-11-deficient embryonic fibroblasts are resistant to apoptosis induced by ectopic expression of caspase-1, suggesting that caspase-11 is an upstream activator of caspase-1. Unlike caspase-1, the expression of caspase-11 is LPS-inducible and it is reasonable to postulate that other members of the family are regulated at the transcriptional or translational level by extracellular stimuli. Recently caspase-11 has been shown to be required for activation of the Nlrp3 inflammasome upon E. coli, V. cholerae and C. rodentium infection. The upstream activators of caspase-11 are TLR4 and TRIF, that modulate enteropathogen-induced inflammasome activation by promoting caspase-11 expression and activation. Formation of ASC foci (specks), a measure of NLRP3/ASC complex formation, requires caspase-11 but not caspase-1 indicating that caspase-11 acts upstream of the NLRP3/ASC complex.
Clone ID: Flamy-1
Swiss prot ID: P70343
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: AG-20B-0060B-C100; AdipoGen Life Sciences; Caspase-11 (mouse); Caspase-4 (human); ICE(rel)-II (human); Protease ICH-2 (human); Protease TX (human); Protease ICH-3 (mouse)