anti-CD103 / Integrin alpha E antibody [Ber-ACT8]

Arigo Biolaboratories

anti-CD103 / Integrin alpha E antibody [Ber-ACT8]

23

Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application

Research Use Only

Monoclonal

Ber-ACT8

1 mg/ml

Unconjugated

>95%

ITGAE

integrin subunit alpha E

antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; CD103; HML-1 antigen; human mucosal lymphocyte antigen 1, alpha polypeptide; HUMINAE; integrin alpha-E; integrin alpha-IEL; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); mucosal lymphocyte 1 antigen

Mouse

IgG1

CD103 / Integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.

Human

-20°C

12352203