anti-CD154 / CD40L antibody [MR-1] (FITC)

Arigo Biolaboratories

anti-CD154 / CD40L antibody [MR-1] (FITC)

23

Flow Cytometry, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking

Research Use Only

Monoclonal

MR-1

0.5 mg/ml

FITC

Cd40lg

CD40 ligand

CD154; Cd40; CD40 ligand; Cd40l; CD40-L; gp3; gp39; HIGM; HIGM1; IGM; IMD; IMD3; Ly-6; Ly62; Ly-62; T-BA; T-BAM; T-cell antigen Gp39; TNF-related activation protein; Tnfs; Tnfsf5; Tnlg8b; TRAP; tumor necrosis factor ligand 8b; tumor necrosis factor ligand superfamily member 5

Hamster

IgG3

CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.

Mouse

2°C to 8°C

12352203