anti-CD2 antibody [LT2]
ARG65477
ApplicationsFlow Cytometry, ImmunoPrecipitation
Product group Antibodies
ReactivityHuman
TargetCD2
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD2 antibody [LT2]
- Delivery Days Customer23
- ApplicationsFlow Cytometry, ImmunoPrecipitation
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDLT2
- Concentration1 mg/ml
- ConjugateUnconjugated
- Estimated Purity>80%
- Gene ID914
- Target nameCD2
- Target descriptionCD2 molecule
- Target synonymsCD2 antigen (p50), sheep red blood cell receptor; erythrocyte receptor; LFA-2; LFA-3 receptor; lymphocyte-function antigen-2; rosette receptor; SRBC; T11; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionCD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203