anti-CD32 antibody [3D3] (PE)
ARG54201
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetFCGR2A
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD32 antibody [3D3] (PE)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3D3
- ConjugateRPE
- Gene ID2212
- Target nameFCGR2A
- Target descriptionFc fragment of IgG receptor IIa
- Target synonymsCD32; CD32A; CDw32; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc gamma receptor RIIa3; FCG2; fc-gamma-RIIa; FcGR; FCGR2; FCGR2A1; fcRII-a; IGFR2; igG Fc receptor II-a; Immunoglobulin G Fc receptor II; low affinity immunoglobulin gamma Fc region receptor II-a
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCD32 (FcgammaRII) is a low affinity receptor for aggregated IgG. It is strongly expressed on monocytes, granulocytes, myeloid and myeloblastic cell lines, and weakly on B cells, CD34+ bone marrow cells, and resting and activated platelets. After binding its ligand, CD32 induces IgG-mediated phagocytosis and oxidative burst in monocytes and neutrophils, whereas in B cells it mediates a negative signal. This polymorphic transmembrane glycoprotein is expressed not only in the activating (CD32a) and inhibitory isoform (CD32b), but also in individual variants with differing avidities for IgG subtypes (e.g. the CD32a131R and CD32a131H allotypes).
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203