anti-CD42b antibody [HIP1]

Arigo Biolaboratories

anti-CD42b antibody [HIP1]

23

Functional Assay, Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application

Research Use Only

Monoclonal

HIP1

1 mg/ml

Unconjugated

>95%

GP1BA

glycoprotein Ib platelet subunit alpha

antigen CD42b-alpha; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; GP1B; GP-Ib alpha; GPIbA; GPIbalpha; mutant platelet membrane glycoprotein Ib-alpha; platelet glycoprotein Ib alpha chain; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha; VWDP

Mouse

IgG1

CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.

-20°C

12352203