anti-CD53 antibody [MEM-53]

Arigo Biolaboratories

anti-CD53 antibody [MEM-53]

23

Functional Assay, Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

MEM-53

1 mg/ml

Unconjugated

>95%

CD53

CD53 molecule

antigen MOX44 identified by monoclonal antibody MRC-OX44; CD53 antigen; CD53 glycoprotein; CD53 tetraspan antigen; cell surface antigen; cell surface glycoprotein CD53; leukocyte surface antigen CD53; MOX44; tetraspanin-25; transmembrane glycoprotein; TSPAN25; tspan-25

Mouse

IgG1

CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumour cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.

-20°C

12352203