anti-CD62P / P-Selectin antibody [AK4] (low endotoxin)

Arigo Biolaboratories

anti-CD62P / P-Selectin antibody [AK4] (low endotoxin)

23

Functional Assay, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

AK4

1 mg/ml

Unconjugated

>95%

SELP

selectin P

CD62; CD62 antigen-like family member P; CD62P; GMP140; GMP-140; granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; GRMP; LECAM3; leukocyte-endothelial cell adhesion molecule 3; PADGEM; platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; PSEL; P-selectin; selectin P (granule membrane protein 140kDa, antigen CD62)

Mouse

IgG1

CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.

Human

-20°C

12352203