anti-CD71 / Transferrin Receptor antibody [MEM-75] (Biotin)

Arigo Biolaboratories

anti-CD71 / Transferrin Receptor antibody [MEM-75] (Biotin)

23

Flow Cytometry

Research Use Only

Monoclonal

MEM-75

1 mg/ml

Biotin

TFRC

transferrin receptor

CD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR

Mouse

IgG1

CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.

Human

2°C to 8°C

12352203