anti-CD97 antibody [MEM-180]

Arigo Biolaboratories

anti-CD97 antibody [MEM-180]

23

Flow Cytometry, ImmunoPrecipitation

Research Use Only

Monoclonal

MEM-180

1 mg/ml

Unconjugated

>95%

ADGRE5

adhesion G protein-coupled receptor E5

adhesion G protein-coupled receptor E5; CD97; CD97 molecule; leukocyte antigen CD97; seven transmembrane helix receptor; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation; TM7LN1

Mouse

IgG1

CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral granulocyte homeostasis.

-20°C

12352203