anti-DCLK1 antibody
ARG54844
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetDCLK1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-DCLK1 antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID9201
- Target nameDCLK1
- Target descriptiondoublecortin like kinase 1
- Target synonymsCL1; CLICK1; DCAMKL1; DCDC3A; DCLK; doublecortin domain-containing protein 3A; doublecortin-like and CAM kinase-like 1; serine/threonine-protein kinase DCLK1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203