anti-GluR1 Subunit phospho (Ser845) antibody

Arigo Biolaboratories

anti-GluR1 Subunit phospho (Ser845) antibody

23

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Polyclonal

Unconjugated

Gria1

glutamate ionotropic receptor AMPA type subunit 1

AMPA-selective glutamate receptor 1; GluA1; GluR1; gluR-1; gluR-A; gluR-K1; glutamate receptor 1; glutamate receptor A; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA1 (alpha 1)

Rabbit

IgG

Phosphorylated

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinaenen et al., 1990; Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. Phosphorylation of Ser845 on GluR1 is thought to be mediated by PKA and phosphorylation of this site increases the conductance of the AMPAR (Roche et al., 1996; Banke et al., 2000). In addition, phosphorylation of this site has been linked to synaptic plasticity as well as learning and memory (Lee at al., 2003; Esteban at al., 2003).

Human, Mouse, Primate, Rat

-20°C

12352203