anti-IL10R subunit alpha antibody [1B1.3a] (azide free)

Arigo Biolaboratories

anti-IL10R subunit alpha antibody [1B1.3a] (azide free)

23

Functional Assay, Flow Cytometry

Research Use Only

Monoclonal

1B1.3a

1 mg/ml

Unconjugated

Il10ra

interleukin 10 receptor, alpha

AW553859; CDw210; CDw210a; Il; IL-10 receptor subunit alpha; Il10r; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10RA; interleukin-10 receptor subunit 1; interleukin-10 receptor subunit alpha; mIL-; mIL-10R

Rat

IgG1

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

Mouse

-20°C

12352203