anti-IL-1alpha (p18) (mouse), mAb (Teo-1)

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Product specifications for - anti-IL-1alpha (p18) (mouse), mAb (Teo-1)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ELISA; Western Blot
Species:	Mouse
Target:	Il1a
Target description:	interleukin 1 alpha
Isotype:	IgG
Source:	Purified from concentrated hybridoma tissue culture supernatant.

Properties:
Purity:	>95% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Form supplied:	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:	-20-¦C

Scientific information:
Scientific info:	Monoclonal Antibody. Recognizes mouse IL-1alpha p18 cleaved and full-length fragments. Isotype: Mouse IgG. Clone: Teo-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner. - The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Clone ID:	Teo-1
Gene ID:	16175
Swiss prot ID:	P01582

Safety information:
MSDS:	MSDS

Additional information:
Synonyms:	IL-1 alpha; Il-1a; interleukin-1 alpha

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Product specifications for - anti-IL-1alpha (p18) (mouse), mAb (Teo-1)