anti-LAG-3 (human), mAb (blocking) (17B4) (preservative free)

Catalog number: AG-20B-0012PF-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 330.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-LAG-3 (human), mAb (blocking) (17B4) (preservative free)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: FACS, FUNC (Blocking), ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoPrecipitation, Western Blot
Clonality: Monoclonal
Isotype: IgG1
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1mg/ml
Form supplied: Liquid. In PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Clone ID: 17B4
Swiss prot ID: P18627
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: AG-20B-0012PF-C100; AdipoGen Life Sciences; Lymphocyte Activation Gene-3; FDC Protein; CD223
Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens: E. Baixeras, et al.; J. Exp. Med. 176, 327 (1992) Read more
Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand: B. Huard, et al.; Immunogenetics 39, 213 (1994) Read more
Characterization of the major histocompatibility complex class II binding site on LAG-3 protein: B. Huard, et al.; PNAS 94, 5744 (1997) Read more
CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling: S. Hannier, et al.; J. Immunol. 161, 4058 (1998) Read more
T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts: C.E. Demeure, et al.; Eur. J. Cancer 37, 1709 (2001) Read more
Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway: E.D. Carlo, et al.; J. Pathol. 205, 82 (2005) Read more
The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells: L. Macon-Lemaitre & F. Triebel; Immunology 115, 170 (2005) Read more
A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors: F. Triebel, et al.; Cancer Lett. 235, 147 (2006) Read more
Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells: J. Bayry, et al.; J. Immunol. 178, 4184 (2007) Read more
Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation: C. Casati, et al.; J. Immunol. 180, 3782 (2008) Read more