anti-NLRP6/NALP6 (human), mAb (Clint-1)

Catalog number: AG-20B-0046-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 360.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-NLRP6/NALP6 (human), mAb (Clint-1)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoHistoChemistry; Western Blot
Species: Human
Target: NLRP6
Target description: NLR family pyrin domain containing 6
Clonality: Monoclonal
Isotype: IgG1 Kappa
Source: Purified from concentrated hybridoma tissue culture supernatant.
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Monoclonal Antibody. Recognizes human NLRP6. Isotype: Mouse IgG1kappa. Clone: Clint-1. Applications: IHC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice. - The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.
Clone ID: Clint-1
Gene ID: 171389
Swiss prot ID: P59044
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: angiotensin II/vasopressin receptor; AVR; CLR11.4; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NALP6; NAVR; NAVR/AVR; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PAN3; PYPAF5; PYRIN-containing APAF1-like protein 5