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anti-NMDAR1 C1 antibody

Research Use Only
ARG52353
Arigo Biolaboratories
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityBovine, Canine, Human, Primate, Rat
TargetGrin1
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-NMDAR1 C1 antibody
  • Delivery Days Customer
    23
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID24408
  • Target name
    Grin1
  • Target description
    glutamate ionotropic receptor NMDA type subunit 1
  • Target synonyms
    GluN1; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; neurotransmitter receptor; NMDA R1 receptor C1 cassette; NMDAR1; NMD-R1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; NR1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The ion channels activated by glutamate that are sensitive to N-methyl-Daspartate (NMDA) are designated NMDA Receptors (NMDAR). The NMDAR plays an essential role in memory and neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). There are a number of different splice variants of the NR1-Subunit (Foldes et al., 1994; Zukin and Bennett, 1995). Differential splicing of three exons in the NR1-Subunit generates up to eight NR1-Subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.
  • Reactivity
    Bovine, Canine, Human, Primate, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203