anti-Polyglutamylation Modification, mAb (GT335)

Catalog number: AG-20B-0020-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 380.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-Polyglutamylation Modification, mAb (GT335)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Electron Microscopy, ImmunoCytoChemistry, ImmunoPrecipitation, Western Blot
Clonality: Monoclonal
Isotype: IgG1 Kappa
Source: Purified from concentrated hybridoma tissue culture supernatant.
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. It is evolutionarily conserved and the most prominent substrate is tubulin, the microtubule (MT) building block. Polyglutamylation has been proposed to be involved in the functional adaptation of MTs, as it occurs within the carboxy-terminal tubulin tails that participate directly in the binding of many structural and motor MT-associated proteins. The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and be involved in cell cycle and cell proliferation.
Clone ID: GT335
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: AG-20B-0020-C100; AdipoGen Life Sciences; Polyglutamylated Tubulin; Glutamylated Tubulin; Postranslational Protein Glutamylation
Distribution of glutamylated alpha and beta-tubulin in mouse tissues using a specific monoclonal antibody, GT335: A. Wolff, et al.; Eur. J. Cell Biol. 59, 425 (1992) Read more
Polyglutamylation of nucleosome assembly proteins: C. Regnard, et al.; J. Biol. Chem. 275, 15969 (2000) Read more
Glutamylated tubulin: diversity of expression and distribution of isoforms: M.L. Kann, et al.; Cell Motil. Cytoskeleton 55, 14 (2003) Read more
Polyglutamylation Is a Post-translational Modification with a Broad Range of Substrates: J. van Dijk, et al.; J. Biol. Chem. 283, 3915 (2008) Read more
Tubulin detyrosination promotes monolayer formation and apical trafficking in epithelial cells: S. Zink, et al.; J. Cell Sci. 125, 5998 (2012) Read more
The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly: T. Kobayashi, et al.; J. Cell Biol. 204, 215 (2014) Read more
CNS axons globally increase axonal transport after peripheral conditioning: F.M. Mar, et al.; J. Neurosci. 34, 5965 (2014) Read more
Microtubule detyrosination guides chromosomes during mitosis: M. Barisic, et al.; Science 348, 6236 (2015) (Supplement) Read more
SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture: M. Hilbert, et al.; Nat. Cell Biol. 18, 393 (2016) Read more