anti-Skeletal Troponin T antibody [T1/61]
ARG22574
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityChicken
TargetTNNT3
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-Skeletal Troponin T antibody [T1/61]
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDT1/61
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID395761
- Target nameTNNT3
- Target descriptiontroponin T3, fast skeletal type
- Target synonymstroponin T type 3 (skeletal, fast); troponin T variant TnTx7-e16; troponin T, fast skeletal muscle isoforms; troponin T3, skeletal, fast
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
- ReactivityChicken
- Storage Instruction-20°C
- UNSPSC12352203