GTX70103 IHC-P Image
GTX70103 IHC-P Image
ATM antibody [2C1] - KO/KD, Orthogonal Validated
GTX70103
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
Overview
- SupplierGeneTex
- Product NameATM antibody [2C1] - KO/KD, Orthogonal Validated
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID2C1
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- ReactivityHuman, Monkey, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors. Molenaar RJ et al., 2018 Apr 1, Clin Cancer ResRead more
- 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. Hsu CC et al., 2012 Jun 29, J Biol ChemRead more
- 7-hydroxy-staurosporine, UCN-01, induces DNA damage response, and autophagy in human osteosarcoma U2-OS cells. Lien WC et al., 2018 Jun, J Cell BiochemRead more
- A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. Bouquet F et al., 2011 Jun 1, J Cell SciRead more
- A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Wang Y et al., 2016 Feb 1, Genes DevRead more
- A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Sajish M et al., 2015 Mar 19, NatureRead more
- A noncatalytic function of the ligation complex during nonhomologous end joining. Cottarel J et al., 2013 Jan 21, J Cell BiolRead more
- A novel role for hSMG-1 in stress granule formation. Brown JA et al., 2011 Nov, Mol Cell BiolRead more
- A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Stewart R et al., 2013 Jun 15, Hum Mol GenetRead more
- A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells. Bakkenist CJ et al., 2015, OncoscienceRead more