GTX110815 IHC-P Image
GTX110815 IHC-P Image
ATP6V1A antibody
GTX110815
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameATP6V1A antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.57 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Activity-independent targeting of mTOR to lysosomes in primary osteoclasts. Wang A et al., 2017 Jun 7, Sci RepRead more
- Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Jewell JL et al., 2015 Jan 9, ScienceRead more
- mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Matsumoto A et al., 2017 Jan 12, NatureRead more
- Neuronal ceroid lipofuscinosis with DNAJC5/CSPalpha mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Henderson MX et al., 2016 Apr, Acta NeuropatholRead more
- Novel c.G630A TCIRG1 mutation causes aberrant splicing resulting in an unusually mild form of autosomal recessive osteopetrosis. Zirngibl RA et al., 2019 Oct, J Cell BiochemRead more
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Rebsamen M et al., 2015 Mar 26, NatureRead more
- The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex. Deng Y et al., 2018 May 15, Hum Mol GenetRead more
- Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to Escherichia coli Through Inflammasome-Mediated Caspase-1 Activation in Macrophages. Yoon SJ et al., 2019, Front ImmunolRead more
- TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation. Hashimoto Y et al., 2018 Jun, Genes CellsRead more