GTX134510 IHC-P Image
beta Amyloid (1-42) antibody - Conformation Specific
GTX134510
Product group Antibodies
Overview
- SupplierGeneTex
- Product Namebeta Amyloid (1-42) antibody - Conformation Specific
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.45 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimers Disease Patients. Dinkel F et al., 2020, Front Aging NeurosciRead more
- Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimers disease. Wang H et al., 2021 May 13, CNS Neurosci TherRead more