BRAF antibody
ORB153753
Product group Antibodies
Overview
- SupplierBiorbyt
- Product NameBRAF antibody
- Delivery Days Customer16
- Applications SupplierWB: 1:500-2000, IHC-P: 1:50-200 IHC-P, WB
- CertificationResearch Use Only
- IsotypeIgG
- Scientific DescriptionRabbit polyclonal antibody to BRAF. B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system. It has been observed that MAPK is activated by B-Raf in response to nerve growth factor. More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity. Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma.
- Storage Instruction-20°C
- UNSPSC12352203