GTX114650 IHC-Fr Image
GTX114650 IHC-Fr Image
Brn2 antibody
GTX114650
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameBrn2 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.2 mg/ml
- IsotypeIgG
- Scientific DescriptionPOU3F2 belongs to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, that occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176) and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the central nervous system (CNS). It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression (Schreiber et al., 1993 [PubMed 8441633]; Atanasoski et al., 1995 [PubMed 7601453]).[supplied by OMIM]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. Wong WT et al., 2017 Mar 21, ElifeRead more
- DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis. Enriquez-Rios V et al., 2017 Jan 25, J NeurosciRead more
- Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival. Tan C et al., 2014, Clin Med Insights OncolRead more
- Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer. Fujino K et al., 2015 Dec, Am J PatholRead more
- Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells. Kitajima R et al., 2020 Apr, Stem Cell ResRead more
- Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Lee Y et al., 2012 Jun, Nat NeurosciRead more
- Nwd1 Regulates Neuronal Differentiation and Migration through Purinosome Formation in the Developing Cerebral Cortex. Yamada S et al., 2020 May 22, iScienceRead more
- Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. Shimada M et al., 2015 Oct 1, EMBO JRead more
- Reliability of human cortical organoid generation. Yoon SJ et al., 2019 Jan, Nat MethodsRead more
- Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions. Wang J et al., 2020 Dec 15, Cell RepRead more