CCM2 antibody [N1C2]

Catalog number: GTX109835_100ul
Brand: GeneTex
Packing: 100 ul
Other sizes: 25 ul
Price: € 334.00
Expected delivery time: 10 days
Quantity:
GTX109835 WB Image
GTX109835 WB Image...

Product specifications for - CCM2 antibody [N1C2]

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot
Species: Human
Host: Rabbit
Target: CCM2
Target description: CCM2 scaffold protein
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Controle: 293T
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 0.4 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID: 83605
Swiss prot ID: Q9BSQ5
Additional information: 
Synonyms: C7orf22; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformations 2 protein; malcavernin; OSM; osmosensing scaffold for MEKK3; PP10187