CD45 antibody

GeneTex

CD45 antibody

10

Western Blot

Research Use Only

Polyclonal

Chicken

IgY

Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity. while the second one seems to affect the substrate specificity of the first one. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth. differentiation. mitotic cycle. and oncogenic transformation. This PTP contains an extracellular domain. a single transmembrane segment and two tandem intracytoplasmic catalytic domains. and thus belongs to receptor type PTP. This protein is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes. or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases. and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene. which encode distinct isoforms. have been reported.

Human

2°C to 8°C,-20°C

12352203