CDC6 antibody, MAb

Biorbyt

CDC6 antibody, MAb

10

Western Blot

Western blot - 1-2 μg/ml - Human - - - WB

Research Use Only

Monoclonal

Clone: DCS-180

100 ug/ml

Mouse

IgG1

Mouse monoclonal antibody to In yeasts, Cdc6 Saccharomyces cerevisiae and Cdc18 Schizosaccharomyces pombe associate with the origin recognition complex ORC proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al. 1998 showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. They conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.

Human

2°C to 8°C,-20°C

12352203