GTX13939 IHC-P Image
GTX13939 IHC-P Image
CENPA antibody [3-19]
GTX13939
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
Product group Antibodies
ReactivityC. Elegans, Chicken, Human
Overview
- SupplierGeneTex
- Product NameCENPA antibody [3-19]
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionCentromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
- ReactivityC. Elegans, Chicken, Human
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. Maehara K et al., 2010 May, Mol Cell BiolRead more
- Chk1 and Mps1 jointly regulate correction of merotelic kinetochore attachments. Petsalaki E et al., 2013 Mar 1, J Cell SciRead more
- Chk1 protects against chromatin bridges by constitutively phosphorylating BLM serine 502 to inhibit BLM degradation. Petsalaki E et al., 2014 Sep 15, J Cell SciRead more
- Chk2 prevents mitotic exit when the majority of kinetochores are unattached. Petsalaki E et al., 2014 May 12, J Cell BiolRead more
- Chmp4c is required for stable kinetochore-microtubule attachments. Petsalaki E et al., 2018 Dec, ChromosomaRead more
- Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint. Petsalaki E et al., 2016 Apr 29, Nat CommunRead more
- Decoding the centromeric nucleosome through CENP-N. Pentakota S et al., 2017 Dec 27, ElifeRead more
- DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. Lawrence KS et al., 2015 Apr, PLoS GenetRead more
- hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability. Li Z et al., 2018 Jul 13, EMBO JRead more
- Insights from biochemical reconstitution into the architecture of human kinetochores. Weir JR et al., 2016 Sep 8, NatureRead more