Overview
- SupplierGeneTex
- Product NameDCK antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionDeoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031. Sarr A et al., 2019 May 21, Sci RepRead more
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues. Suksawat M et al., 2019, PLoS OneRead more
- Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML. Kurata M et al., 2016 Nov 3, Sci RepRead more