GTX130695 WB Image
GTX130695 WB Image
DHCR7 antibody
GTX130695
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameDHCR7 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.86 mg/ml
- IsotypeIgG
- Scientific DescriptionThe DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development (Moebius et al., 1998 [PubMed 9465114]).[supplied by OMIM]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH. Hathazi D et al., 2021 Sep 4, BrainRead more
- New Inhibitory Effect of Latilactobacillus sakei UONUMA on the Cholesterol Biosynthesis Pathway in Human HepG2 Cells. Ohta-Shimizu M et al., 2021, Biol Pharm BullRead more