Overview
- SupplierGeneTex
- Product NameDoublecortin antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.72 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimers Disease Mice. Polis B et al., 2020 Feb 8, Int J Mol SciRead more
- Delivery of exogenous proteins by mesenchymal stem cells attenuates early memory deficits in a murine model of Alzheimers disease. Li A et al., 2020 Feb, Neurobiol AgingRead more
- Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication. Chen M et al., 2020 Sep, Eur Respir JRead more
- Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication. Chen M et al., 2020 May 9, bioRxivRead more
- Stigmasterol promotes neuronal migration via reelin signaling in neurosphere migration assays. Haque MN et al., 2018 Nov 15, Nutr NeurosciRead more