DR5 antibody [DR5-01-1]
GTX80178
Overview
- SupplierGeneTex
- Product NameDR5 antibody [DR5-01-1]
- Delivery Days Customer10
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDDR5-01-1
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Chemotherapeutic Agents Sensitize Resistant Cancer Cells to the DR5-Specific Variant DR5-B more Efficiently than to TRAIL by Modulating the Surface Expression of Death and Decoy Receptors. ?rtykov ?? et al., 2020 Apr 30, Cancers (Basel)Read more
- Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile. Yagolovich AV et al., 2020 Apr, Transl OncolRead more