Overview
- SupplierGeneTex
- Product NameE2F3 antibody [N2C3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.28 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- MicroRNA-302b-inhibited E2F3 transcription factor is related to all trans retinoic acid-induced glioma cell apoptosis. Chen PH et al., 2014 Dec, J NeurochemRead more
- miR-497 suppresses cycle progression through an axis involving CDK6 in ALK-positive cells. Hoareau-Aveilla C et al., 2019 Feb, HaematologicaRead more