Factor X antibody - Orthogonal, Overexpression Validated | GTX110300

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Product specifications for - Factor X antibody - Orthogonal, Overexpression Validated

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Western Blot
Species:	Human, Mouse
Host:	Rabbit
Target:	F10
Target description:	coagulation factor X
Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG

Properties:
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1.05 mg/ml
Storage instructions:	2-¦C to 8-¦C, -20-¦C or -80-¦C

Scientific information:
Scientific info:	This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq]
Gene ID:	2159
Swiss prot ID:	P00742

Additional information:
Synonyms:	coagulation factor X; factor X; factor Xa; FX; FXA; prothrombinase; Stuart factor; Stuart-Prower factor

"A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X." Matsui H et al., 2012 May, Biomaterials

"A plasma proteolysis pathway comprising blood coagulation proteases." Yang L et al., 2016 Jul 5, Oncotarget

"Anticoagulants inhibit proteolytic clearance of plasma amyloid beta." Yang L et al., 2018 Jan 19, Oncotarget

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Factor X antibody - Orthogonal, Overexpression Validated

Product specifications for - Factor X antibody - Orthogonal, Overexpression Validated