GTX110128 WB Image
GTX110128 WB Image
Fumarate hydratase antibody [N2C2], Internal
GTX110128
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameFumarate hydratase antibody [N2C2], Internal
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Bcl2l10 induces metabolic alterations in ovarian cancer cells by regulating the TCA cycle enzymes SDHD and IDH1. Lee SY et al., 2021 Apr, Oncol RepRead more
- The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-kappaB signaling. Shanmugasundaram K et al., 2014 Aug 29, J Biol ChemRead more
- Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the alpha-Ketoglutarate Signaling Pathway. Tseng CW et al., 2018 Jun 1, Cancer ResRead more