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GTX16315 IHC-P Image
GTX16315 IHC-P Image
GTX16315 IHC-P Image

GCLC antibody, N-term

Research Use Only
GTX16315
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
Price on request
Packing Size
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    GeneTex
  • Product Name
    GCLC antibody, N-term
  • Delivery Days Customer
    10
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5-1 mg/ml
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-kappaB and upregulation of HO-1 signaling in TNF-alpha-activated human endothelial cells. Yang HL et al., 2015 Nov 1, Biochem Pharmacol
    Read more
  • Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway. Wu YL et al., 2018 Feb 1, Free Radic Biol Med
    Read more
  • Caveolin-1 Expression Ameliorates Nephrotic Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia. Chen YH et al., 2016, PLoS One
    Read more
  • Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated Human keratinocytes. Hseu YC et al., 2015 Sep, Free Radic Biol Med
    Read more
  • Hericium erinaceus Inhibits TNF-alpha-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-kappaB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells. Chang HC et al., 2016, Oxid Med Cell Longev
    Read more
  • M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice. Rachakonda V et al., 2015 Sep 16, Sci Rep
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  • M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury. Urrunaga NH et al., 2015 Jan, Free Radic Biol Med
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  • Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling. Wu CT et al., 2019, Oxid Med Cell Longev
    Read more
  • The Antiaging Activity of Ergothioneine in UVA-Irradiated Human Dermal Fibroblasts via the Inhibition of the AP-1 Pathway and the Activation of Nrf2-Mediated Antioxidant Genes. Hseu YC et al., 2020, Oxid Med Cell Longev
    Read more
  • The in vitro and in vivo depigmenting activity of Coenzyme Q10 through the down-regulation of alpha-MSH signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated skin keratinocytes. Hseu YC et al., 2019 Jun, Biochem Pharmacol
    Read more