Overview
- SupplierGeneTex
- Product NameHer4 / ErbB4 antibody [C1C3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.97 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- The significance of Her2 on androgen receptor protein stability in the transition of androgen requirement in prostate cancer cells. Hsu FN et al., 2011 May, Am J Physiol Endocrinol MetabRead more