GTX111677 WB Image
GTX111677 WB Image
Lamin A + C antibody
GTX111677
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameLamin A + C antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- High glucose-induced proteome alterations in hepatocytes and its possible relevance to diabetic liver disease. Chen JY et al., 2013 Nov, J Nutr BiochemRead more
- Regulation of somatostatin expression by vitamin D3 and valproic acid in human adipose-derived mesenchymal stem cells. Doering L et al., 2019 Aug 6, Stem Cell Res TherRead more
- TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops. Lee YW et al., 2018 Feb, Nat Struct Mol BiolRead more